1Discovery of Kasugamycin as a Potent Inhibitor of Glycoside Hydrolase Family 18 Chitinases

作者： Qi, Huitang; Ding, Yi; Liu, Tian; Yang, Qing; Yang, Qing; Jiang, Xi; Yang, Qing; SCI

机构： Dalian Univ Technol, Sch Bioengn, Dalian, Peoples R China; Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modem Agr, Shenzhen, Peoples R China;

来源：FRONTIERS IN MOLECULAR BIOSCIENCES

关键词： kasugamycin; chitinase; glycoside hydrolase; inhibitor; target

年份：2021

2Discovery of Azo-Aminopyrimidines as Novel and Potent Chitinase Of Chi-h Inhibitors via Structure-Based Virtual Screening and Rational Lead Optimization

作者： Dong, Lili; Liu, Yaxin; Li, Jingjing; Wang, Yizhen; Shi, Jiakun; Liu, Jiaxin; Ma, Shujie; Zhang, Lihui; Dong, Jingao; Jiang, Xi; Chen, Wei; Yang, Qing; Jiang, Xi; Yang, Qing; Shen, Shengqiang; SCI

机构： Hebei Agr Univ, Coll Plant Protect, State Key Lab North China Crop Improvement & Regul, Baoding 071001, Peoples R China; Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr, Shenzhen 518120, Peoples R China; Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100091, Peoples R China;

来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

关键词： virtual screening; aminopyrimidine derivatives; chitinase; Of Chi-h; inhibitor; insecticidal activity

3Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase

作者： Chen, Lei; Zhou, Yong; Jiang, Xi; Duan, Yanwei; Yang, Qing; Liu, Tian; Chen, Lei; Zhou, Yong; Jiang, Xi; Duan, Yanwei; Yang, Qing; Yang, Qing; SCI

机构： Dalian Univ Technol, Sch Life Sci & Biotechnol, State Key Lab Fine Chem Engn, 2 Linggong Rd, Dalian 116024, Peoples R China; Dalian Univ Technol, Sch Software, 2 Linggong Rd, Dalian 116024, Peoples R China; Dalian Univ Technol, Sch Sof;

来源：JOURNAL OF BIOLOGICAL CHEMISTRY

4A Novel Scaffold for Developing Specific or Broad-Spectrum Chitinase Inhibitors

作者： Liu, Tian; Yang, Qing; Jiang, Xi; Liu, Tian; Yang, Qing; Yang, Qing; Kumar, Ashutosh; Zhang, Kam Y. J.; SCI

机构： Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China; Dalian Univ Technol, Sch Life Sci & Biotechnol, 2 Linggong Rd, Dalian 116024, Peoples R China; Chinese Acad Agr Sci, Inst Plant Protect, Beijing 100193, Peoples R China; RIICEN, Ctr Life Sci Technol, Struct Bioinformat Team, 1-7-22 Suehiro, Yokohama, Kanagawa 2300045, Japan;

来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING

5Discovery of novel inhibitors targeting nematode chitinase CeCht1: Virtual screening, biological evaluation, and molecular dynamics simulation

作者： Shen, Shengqiang; Ding, Baokang; Yang, Meiling; Dong, Lili; Jiang, Xi; Yang, Qing; Jiang, Xi; Yang, Qing; SCI

机构： Peking Univ, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China; Hebei Agr Univ, Coll Plant Protect, State Key Lab North China Crop Improvement & Regul, Baoding, Peoples R China; Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Shenzhen Branch, Guangdong Lab Lingnan Modern Agr, Shenzhen, Peoples R China;

来源：FRONTIERS IN CHEMISTRY

关键词： nematicide; chitinase; inhibitor; CeCht1; virtual screening; inhibitory mechanism

年份：2022

6Pocket-based Lead Optimization Strategy for the Design and Synthesis of Chitinase Inhibitors

作者： Hu, Song; Ling, Yun; He, Xiongkui; Zhang, Li; Jiang, Xi; Liu, Tian; Yang, Qing; Yang, Qing; SCI

机构： China Agr Univ, Dept Appl Chem, Coll Sci, Beijing 100193, Peoples R China; Dalian Univ Technol, Sch Life Sci & Biotechnol, Dalian 116024, Peoples R China; Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China;

来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

关键词： chitinase; lead optimization; inhibitors; pesticide; Ostrinia furnacalis

年份：2019

7Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1

作者： Chen, Wei; Chen, Qi; Yang, Qing; Kumar, Ashutosh; Zhang, Kam Y. J.; Jiang, Xi; Yang, Qing; Yang, Qing; SCI

机构： Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China; RIKEN, Lab Struct Bioinformat, Ctr Biosyst Dynam Res, Yokohama, Kanagawa 2300045, Japan; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch, Shenzhen, Peoples R China; Dalian Univ Technol, Sch Bioengn, Dalian, Peoples R China;

来源：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

关键词： Nematode chitinase; inhibitor; inhibitory mechanism; structural optimisation

年份：2021

8A Series of Compounds Bearing a Dipyrido-Pyrimidine Scaffold Acting as Novel Human and Insect Pest Chitinase Inhibitors

作者： Kumar, Ashutosh; Zhang, Kam Y. J.; Yang, Qing; Jiang, Xi; Liu, Tian; Yang, Qing; Motomura, Yasutaka; Motomura, Yasutaka; Moro, Kazuyo; Zhou, Yong; Moro, Kazuyo; SCI

机构： RIKEN, Ctr Biosyst Dynam Res, Lab Struct Bioinformat, Yokohama, Kanagawa 2300045, Japan; Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, Beijing 100193, Peoples R China; Dalian Univ Technol, Sch Bioengn, Beijing 116024, Peoples R China; RIKEN, Ctr Integrat Med Sci, Lab Innate Immune Syst, Yokohama, Kanagawa 2300045, Japan; Osaka Univ, Grad Sch Med, Dept Microbiol & Immunol, Lab Innate Immune Syst, Osaka 5650871, Japan; Dalian Univ Technol, Sch Software, Dalian 116024, Peoples R China;

来源：JOURNAL OF MEDICINAL CHEMISTRY

年份：2020

9X-ray Structure and Molecular Docking Guided Discovery of Novel Chitinase Inhibitors with a Scaffold of Dipyridopyrimidine-3-carboxamide

作者： Yuan, Pengtao; Shao, Xusheng; Qian, Xuhong; Jiang, Xi; Wang, Siyu; Yang, Qing; Shao, Xusheng; Qian, Xuhong; Qian, Xuhong; SCI

机构： East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch, Shenzhen 518120, Peoples R China; East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China; East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China;

来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

关键词： chitinase; inhibitor; X-ray structure; pest control

年份：2020

10Glycoside hydrolase family 18 chitinases: The known and the unknown

作者： Chen, Wei; Yang, Qing; Yang, Qing; Jiang, Xi; Yang, Qing; SCI

机构： Chinese Acad Agr Sci, Inst Plant Protect, State Key Lab Biol Plant Dis & Insect Pests, 2 West Yuanmingyuan Rd, Beijing 100193, Peoples R China; Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Guangdong Lab Lingnan Modern Agr, Shenzhen Branch, 7 Pengfei Rd, Shenzhen 518120, Peoples R China; Dalian Univ Technol, Sch Bioengn, 2 Linggong Rd, Dalian 116024, Peoples R China;

来源：BIOTECHNOLOGY ADVANCES

关键词： Chitinase; Glycoside hydrolase; Physiological function; Crystal structure; Catalytic mechanism; Inhibitor

年份：2020